Crystal Structure of a Two-domain Fragment of Hepatocyte Growth Factor Activator Inhibitor-1: FUNCTIONAL INTERACTIONS BETWEEN THE KUNITZ-TYPE INHIBITOR DOMAIN-1 AND THE NEIGHBORING POLYCYSTIC KIDNEY DISEASE-LIKE DOMAIN

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is a type I transmembrane protein and inhibitor of several serine proteases, including hepatocyte growth factor activator and matriptase. The protein is essential for development as knock-out mice die in utero due to placental defects caused by...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hong, Zebin, De Meulemeester, Laura, Jacobi, Annemarie, Pedersen, Jan Skov, Morth, J. Preben, Andreasen, Peter A., Jensen, Jan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933187/
https://ncbi.nlm.nih.gov/pubmed/27189939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.707240
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