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Crystal structure of truncated aspartate transcarbamoylase from Plasmodium falciparum
The de novo pyrimidine-biosynthesis pathway of Plasmodium falciparum is a promising target for antimalarial drug discovery. The parasite requires a supply of purines and pyrimidines for growth and proliferation and is unable to take up pyrimidines from the host. Direct (or indirect) inhibition of de...
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| Udgivet i: | Acta Crystallogr F Struct Biol Commun |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
International Union of Crystallography
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4933002/ https://ncbi.nlm.nih.gov/pubmed/27380369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X16008475 |
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