Structures of trehalose-6-phosphate phosphatase from pathogenic fungi reveal the mechanisms of substrate recognition and catalysis

Trehalose is a disaccharide essential for the survival and virulence of pathogenic fungi. The biosynthesis of trehalose requires trehalose-6-phosphate synthase, Tps1, and trehalose-6-phosphate phosphatase, Tps2. Here, we report the structures of the N-terminal domain of Tps2 (Tps2NTD) from Candida a...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Miao, Yi, Tenor, Jennifer L., Toffaletti, Dena L., Washington, Erica J., Liu, Jiuyu, Shadrick, William R., Schumacher, Maria A., Lee, Richard E., Perfect, John R., Brennan, Richard G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932955/
https://ncbi.nlm.nih.gov/pubmed/27307435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601774113
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