Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate analogue...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Miao, Yi, Tenor, Jennifer L., Toffaletti, Dena L., Maskarinec, Stacey A., Liu, Jiuyu, Lee, Richard E., Perfect, John R., Brennan, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527307/
https://ncbi.nlm.nih.gov/pubmed/28743811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00643-17
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