Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

The disaccharide trehalose is critical to the survival of pathogenic fungi in their human host. Trehalose-6-phosphate synthase (Tps1) catalyzes the first step of trehalose biosynthesis in fungi. Here, we report the first structures of eukaryotic Tps1s in complex with substrates or substrate analogue...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:mBio
Auteurs principaux: Miao, Yi, Tenor, Jennifer L., Toffaletti, Dena L., Maskarinec, Stacey A., Liu, Jiuyu, Lee, Richard E., Perfect, John R., Brennan, Richard G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5527307/
https://ncbi.nlm.nih.gov/pubmed/28743811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00643-17
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires