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VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

Allelic exclusion underpins antigenic variation and immune evasion in African trypanosomes. These bloodstream parasites use RNA polymerase-I (pol-I) to transcribe just one telomeric variant surface glycoprotein (VSG) gene at a time, producing superabundant and switchable VSG coats. We identified try...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Glover, Lucy, Hutchinson, Sebastian, Alsford, Sam, Horn, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932947/
https://ncbi.nlm.nih.gov/pubmed/27226299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1600344113
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