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Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids

Cardiotonic steroids (CTS) are clinically important drugs for the treatment of heart failure owing to their potent inhibition of cardiac Na(+), K(+)-ATPase (NKA). Bufadienolides constitute one of the two major classes of CTS, but little is known about how they interact with NKA. We report a remarkab...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tang, Hong-Jin, Ruan, Li-Jun, Tian, Hai-Yan, Liang, Guang-Ping, Ye, Wen-Cai, Hughes, Eleri, Esmann, Mikael, Fedosova, Natalya U., Chung, Tse-Yu, Tzen, Jason T. C., Jiang, Ren-Wang, Middleton, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932606/
https://ncbi.nlm.nih.gov/pubmed/27377465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29155
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