Expressing Constitutively Active Rheb in Adult Dorsal Root Ganglion Neurons Enhances the Integration of Sensory Axons that Regenerate Across a Chondroitinase-Treated Dorsal Root Entry Zone Following Dorsal Root Crush

While the peripheral branch of dorsal root ganglion neurons (DRG) can successfully regenerate after injury, lesioned central branch axons fail to regrow across the dorsal root entry zone (DREZ), the interface between the dorsal root and the spinal cord. This lack of regeneration is due to the limite...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Wu, Di, Klaw, Michelle C., Kholodilov, Nikolai, Burke, Robert E., Detloff, Megan R., Côté, Marie-Pascale, Tom, Veronica J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932115/
https://ncbi.nlm.nih.gov/pubmed/27458339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00049
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