Combining Constitutively Active Rheb Expression and Chondroitinase Promotes Functional Axonal Regeneration after Cervical Spinal Cord Injury

After spinal cord injury (SCI), severed axons in the adult mammalian CNS are unable to mount a robust regenerative response. In addition, the glial scar at the lesion site further restricts the regenerative potential of axons. We hypothesized that a combinatorial approach coincidentally targeting th...

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Detalles Bibliográficos
Publicado en:Mol Ther
Autores principales: Wu, Di, Klaw, Michelle C., Connors, Theresa, Kholodilov, Nikolai, Burke, Robert E., Côté, Marie-Pascale, Tom, Veronica J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768590/
https://ncbi.nlm.nih.gov/pubmed/28967557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.08.011
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