Hypoxia-upregulated microRNA-630 targets Dicer, leading to increased tumor progression

MicroRNAs (miRNAs) are small RNA molecules that affect cellular processes by controlling gene expression. Recent studies have shown that hypoxia downregulates Drosha and Dicer, key enzymes in miRNA biogenesis, causing a decreased pool of miRNAs in cancer, and resulting in increased tumor growth and...

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Bibliografiset tiedot
Julkaisussa:Oncogene
Päätekijät: Rupaimoole, Rajesha, Ivan, Cristina, Yang, Da, Gharpure, Kshipra M., Wu, Sherry Y., Pecot, Chad V., Previs, Rebecca A., Nagaraja, Archana S., Armaiz-Pena, Guillermo N, McGuire, Michael, Pradeep, Sunila, Mangala, Lingegowda S., Rodriguez-Aguayo, Cristian, Huang, Li, Bar-Eli, Menashe, Zhang, Wei, Lopez-Berestein, Gabriel, Calin, George A., Sood, Anil K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931989/
https://ncbi.nlm.nih.gov/pubmed/26725326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.492
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