Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specif...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Reis, Felipe C. G., Branquinho, Jéssica L. O., Brandão, Bruna B., Guerra, Beatriz A., Silva, Ismael D., Frontini, Andrea, Thomou, Thomas, Sartini, Loris, Cinti, Saverio, Kahn, C. Ronald, Festuccia, William T., Kowaltowski, Alicia J., Mori, Marcelo A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931827/
https://ncbi.nlm.nih.gov/pubmed/27241713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100970
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