Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brandão, Bruna B., Madsen, Søren, Rabiee, Atefeh, Oliverio, Matteo, Ruiz, Gabriel P., Ferrucci, Danilo L., Branquinho, Jéssica L., Razolli, Daniela, Pinto, Silas, Nielsen, Thomas S., Festuccia, William T., Martins, Adriano S., Guerra, Beatriz A., Knittel, Thiago L., Søgaard, Ditte, Larsen, Steen, Helge, Jørn W., Brandauer, Josef, Velloso, Lício A., Emanuelli, Brice, Kornfeld, Jan-Wilhelm, Kahn, C. Ronald, Vienberg, Sara G., Zierath, Juleen R., Treebak, Jonas T., Mori, Marcelo A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519274/
https://ncbi.nlm.nih.gov/pubmed/32900951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011243117
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