Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipo...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Brandão, Bruna B., Madsen, Søren, Rabiee, Atefeh, Oliverio, Matteo, Ruiz, Gabriel P., Ferrucci, Danilo L., Branquinho, Jéssica L., Razolli, Daniela, Pinto, Silas, Nielsen, Thomas S., Festuccia, William T., Martins, Adriano S., Guerra, Beatriz A., Knittel, Thiago L., Søgaard, Ditte, Larsen, Steen, Helge, Jørn W., Brandauer, Josef, Velloso, Lício A., Emanuelli, Brice, Kornfeld, Jan-Wilhelm, Kahn, C. Ronald, Vienberg, Sara G., Zierath, Juleen R., Treebak, Jonas T., Mori, Marcelo A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7519274/
https://ncbi.nlm.nih.gov/pubmed/32900951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011243117
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