Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice

Aging increases the risk of type 2 diabetes, and this can be prevented by dietary restriction (DR). We have previously shown that DR inhibits the downregulation of miRNAs and their processing enzymes - mainly Dicer - that occurs with aging in mouse white adipose tissue (WAT). Here we used fat-specif...

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Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Reis, Felipe C. G., Branquinho, Jéssica L. O., Brandão, Bruna B., Guerra, Beatriz A., Silva, Ismael D., Frontini, Andrea, Thomou, Thomas, Sartini, Loris, Cinti, Saverio, Kahn, C. Ronald, Festuccia, William T., Kowaltowski, Alicia J., Mori, Marcelo A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931827/
https://ncbi.nlm.nih.gov/pubmed/27241713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.100970
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