Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment

Platelet factor 4 (PF4) has been recently shown to inhibit infection by a broad range of human immunodeficiency virus type 1 (HIV-1) isolates in vitro. We found that the inhibitory effects of PF4 are limited to a defined concentration range where PF4 exists largely in a monomeric state. Under these...

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Detalhes bibliográficos
Publicado no:AIDS Res Hum Retroviruses
Main Authors: Parker, Zahra F., Rux, Ann H., Riblett, Amber M., Lee, Fang-Hua, Rauova, Lubica, Cines, Douglas B., Poncz, Mortimer, Sachais, Bruce S., Doms, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931766/
https://ncbi.nlm.nih.gov/pubmed/26847431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2015.0344
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