p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

p62/Sqstm1 is a multifunctional protein involved in cell survival, growth and death, that is degraded by autophagy. Amplification of the p62/Sqstm1 gene, and aberrant accumulation and phosphorylation of p62/Sqstm1, have been implicated in tumour development. Herein, we reveal the molecular mechanism...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Nat Commun
المؤلفون الرئيسيون: Saito, Tetsuya, Ichimura, Yoshinobu, Taguchi, Keiko, Suzuki, Takafumi, Mizushima, Tsunehiro, Takagi, Kenji, Hirose, Yuki, Nagahashi, Masayuki, Iso, Tetsuro, Fukutomi, Toshiaki, Ohishi, Maki, Endo, Keiko, Uemura, Takefumi, Nishito, Yasumasa, Okuda, Shujiro, Obata, Miki, Kouno, Tsuguka, Imamura, Riyo, Tada, Yukio, Obata, Rika, Yasuda, Daisuke, Takahashi, Kyoko, Fujimura, Tsutomu, Pi, Jingbo, Lee, Myung-Shik, Ueno, Takashi, Ohe, Tomoyuki, Mashino, Tadahiko, Wakai, Toshifumi, Kojima, Hirotatsu, Okabe, Takayoshi, Nagano, Tetsuo, Motohashi, Hozumi, Waguri, Satoshi, Soga, Tomoyoshi, Yamamoto, Masayuki, Tanaka, Keiji, Komatsu, Masaaki
التنسيق: Artigo
اللغة:Inglês
منشور في: Nature Publishing Group 2016
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC4931237/
https://ncbi.nlm.nih.gov/pubmed/27345495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12030
الوسوم: إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!

مواد مشابهة