Prognostic Impact of IL-6 Genetic Variants in Patients with Metastatic Colorectal Cancer Treated with Bevacizumab-Based Chemotherapy

BACKGROUND: The IL-6/STAT3 axis promotes inflammation, angiogenesis, and cancer. The effect of genetic variants within this pathway on benefit from anti-angiogenic cancer therapy is unknown. We tested whether single nucleotide polymorphisms (SNPs) in genes involved in IL-6/STAT3 signaling can predic...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Matsusaka, Satoshi, Hanna, Diana L., Cao, Shu, Zhang, Wu, Yang, Dongyun, Ning, Yan, Sunakawa, Yu, Okazaki, Satoshi, Berger, Martin D., Miyamato, Yuji, Parekh, Anish, Stintzing, Sebastian, Loupakis, Fotios, Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930688/
https://ncbi.nlm.nih.gov/pubmed/26839145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2422
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