Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents. With clinical trials of several of these experimental compounds underway, i...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Breast Cancer Res
Main Authors: Hu, Zhi, Mao, Jian-Hua, Curtis, Christina, Huang, Ge, Gu, Shenda, Heiser, Laura, Lenburg, Marc E., Korkola, James E., Bayani, Nora, Samarajiwa, Shamith, Seoane, Jose A., A. Dane, Mark, Esch, Amanda, Feiler, Heidi S., Wang, Nicholas J., Hardwicke, Mary Ann, Laquerre, Sylvie, Jackson, Jeff, W. Wood, Kenneth, Weber, Barbara, Spellman, Paul T., Aparicio, Samuel, Wooster, Richard, Caldas, Carlos, Gray, Joe W.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930593/
https://ncbi.nlm.nih.gov/pubmed/27368372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-016-0728-y
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares