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Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes
BACKGROUND: The multi-arm multi-stage (MAMS) design described by Royston et al. [Stat Med. 2003;22(14):2239–56 and Trials. 2011;12:81] can accelerate treatment evaluation by comparing multiple treatments with a control in a single trial and stopping recruitment to arms not showing sufficient promise...
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| Опубликовано в: : | Trials |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4930581/ https://ncbi.nlm.nih.gov/pubmed/27369182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-016-1382-5 |
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