Identification of small molecule inhibitors that block the Toxoplasma gondii rhoptry kinase ROP18

The protozoan parasite Toxoplasma gondii secretes a family of serine-threonine protein kinases into its host cell in order to disrupt signaling and alter immune responses. One prominent secretory effector is the rhoptry protein 18 (ROP18), a serine-threonine kinase that phosphorylates immunity relat...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Simpson, Catherine, Jones, Nathaniel G., Hull-Ryde, Emily A., Kireev, Dmitri, Stashko, Michael, Tang, Keliang, Janetka, Jim, Wildman, Scott A., Zuercher, William J., Schapira, Matthieu, Hui, Raymond, Janzen, William, Sibley, L. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930114/
https://ncbi.nlm.nih.gov/pubmed/27379343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00102
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