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Toxicities of chimeric antigen receptor T cells: recognition and management

Chimeric antigen receptor (CAR) T cells can produce durable remissions in hematologic malignancies that are not responsive to standard therapies. Yet the use of CAR T cells is limited by potentially severe toxicities. Early case reports of unexpected organ damage and deaths following CAR T-cell ther...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Brudno, Jennifer N., Kochenderfer, James N.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929924/
https://ncbi.nlm.nih.gov/pubmed/27207799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-703751
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