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CD19-targeted CAR T-cell therapeutics for hematologic malignancies: interpreting clinical outcomes to date

Adoptive transfer of T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 has produced impressive results in treating patients with B-cell malignancies. Although these CAR-modified T cells target the same antigen, the designs of CARs vary as well as several key as...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Park, Jae H., Geyer, Mark B., Brentjens, Renier J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929923/
https://ncbi.nlm.nih.gov/pubmed/27207800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-02-629063
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