Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example

[Image: see text] Fluorinated tyrosines (F(n)Y’s, n = 2 and 3) have been site-specifically incorporated into E. coli class Ia ribonucleotide reductase (RNR) using the recently evolved M. jannaschii Y-tRNA synthetase/tRNA pair. Class Ia RNRs require four redox active Y’s, a stable Y radical (Y·) in t...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Oyala, Paul H., Ravichandran, Kanchana R., Funk, Michael A., Stucky, Paul A., Stich, Troy A., Drennan, Catherine L., Britt, R. David, Stubbe, JoAnne
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2016
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929525/
https://ncbi.nlm.nih.gov/pubmed/27276098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b03605
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