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Polysaccharide Nanoparticles for Efficient siRNA Targeting in Cancer Cells by Supramolecular pK(a) Shift

Biomacromolecular pK(a) shifting is considered as one of the most ubiquitous processes in biochemical events, e.g., the enzyme-catalyzed reaction and protein conformational stabilization. In this paper, we report on the construction of biocompatible polysaccharide nanoparticle with targeting ability...

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Publicat a:Sci Rep
Autors principals: Zhang, Ying-Ming, Yang, Yang, Zhang, Yu-Hui, Liu, Yu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929451/
https://ncbi.nlm.nih.gov/pubmed/27363811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28848
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