Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these l...

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Publicat a:Sci Adv
Autors principals: Andlauer, Till F. M., Buck, Dorothea, Antony, Gisela, Bayas, Antonios, Bechmann, Lukas, Berthele, Achim, Chan, Andrew, Gasperi, Christiane, Gold, Ralf, Graetz, Christiane, Haas, Jürgen, Hecker, Michael, Infante-Duarte, Carmen, Knop, Matthias, Kümpfel, Tania, Limmroth, Volker, Linker, Ralf A., Loleit, Verena, Luessi, Felix, Meuth, Sven G., Mühlau, Mark, Nischwitz, Sandra, Paul, Friedemann, Pütz, Michael, Ruck, Tobias, Salmen, Anke, Stangel, Martin, Stellmann, Jan-Patrick, Stürner, Klarissa H., Tackenberg, Björn, Then Bergh, Florian, Tumani, Hayrettin, Warnke, Clemens, Weber, Frank, Wiendl, Heinz, Wildemann, Brigitte, Zettl, Uwe K., Ziemann, Ulf, Zipp, Frauke, Arloth, Janine, Weber, Peter, Radivojkov-Blagojevic, Milena, Scheinhardt, Markus O., Dankowski, Theresa, Bettecken, Thomas, Lichtner, Peter, Czamara, Darina, Carrillo-Roa, Tania, Binder, Elisabeth B., Berger, Klaus, Bertram, Lars, Franke, Andre, Gieger, Christian, Herms, Stefan, Homuth, Georg, Ising, Marcus, Jöckel, Karl-Heinz, Kacprowski, Tim, Kloiber, Stefan, Laudes, Matthias, Lieb, Wolfgang, Lill, Christina M., Lucae, Susanne, Meitinger, Thomas, Moebus, Susanne, Müller-Nurasyid, Martina, Nöthen, Markus M., Petersmann, Astrid, Rawal, Rajesh, Schminke, Ulf, Strauch, Konstantin, Völzke, Henry, Waldenberger, Melanie, Wellmann, Jürgen, Porcu, Eleonora, Mulas, Antonella, Pitzalis, Maristella, Sidore, Carlo, Zara, Ilenia, Cucca, Francesco, Zoledziewska, Magdalena, Ziegler, Andreas, Hemmer, Bernhard, Müller-Myhsok, Bertram
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928990/
https://ncbi.nlm.nih.gov/pubmed/27386562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1501678
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