Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. Attenuation of experimental colitis by capsazepine (CPZ) has long been attributed to its antagonistic action on TRPV1 and associated inhibition of neurogenic inflammation. I...

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Pubblicato in:Sci Rep
Autori principali: Kistner, Katrin, Siklosi, Norbert, Babes, Alexandru, Khalil, Mohammad, Selescu, Tudor, Zimmermann, Katharina, Wirtz, Stefan, Becker, Christoph, Neurath, Markus F., Reeh, Peter W., Engel, Matthias A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928060/
https://ncbi.nlm.nih.gov/pubmed/27356469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28621
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