Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas

Osteosarcoma is a rare disease diagnosed as malignant bone tumor. It is generally refractory to chemotherapy, which contributes to its poor prognosis. The reversal of chemoresistance is a major clinical challenge to improve the prognostic outcome of osteosarcoma patients. We developed a tumor-specif...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Osaki, Shuhei, Tazawa, Hiroshi, Hasei, Joe, Yamakawa, Yasuaki, Omori, Toshinori, Sugiu, Kazuhisa, Komatsubara, Tadashi, Fujiwara, Tomohiro, Sasaki, Tsuyoshi, Kunisada, Toshiyuki, Yoshida, Aki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928055/
https://ncbi.nlm.nih.gov/pubmed/27356624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28953
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