Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction

Osteosarcoma is an aggressive malignant bone tumor that causes bone destruction. Although tumor‐specific replicating oncolytic adenovirus OBP‐301 induces an antitumor effect in an osteosarcoma tumor, it cannot prevent bone destruction. Zoledronic acid (ZOL) is a clinically available agent that inhib...

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Bibliographische Detailangaben
Veröffentlicht in:Cancer Sci
Hauptverfasser: Yamakawa, Yasuaki, Tazawa, Hiroshi, Hasei, Joe, Osaki, Shuhei, Omori, Toshinori, Sugiu, Kazuhisa, Komatsubara, Tadashi, Uotani, Kouji, Fujiwara, Tomohiro, Yoshida, Aki, Kunisada, Toshiyuki, Urata, Yasuo, Kagawa, Shunsuke, Ozaki, Toshifumi, Fujiwara, Toshiyoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5581539/
https://ncbi.nlm.nih.gov/pubmed/28685948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13316
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