Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human β-cell regeneration in vivo. Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) indu...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:J Diabetes Res
Main Authors: Ansarullah, Free, Colette, Christopherson, Jenica, Chen, Quanhai, Gao, Jie, Liu, Chengyang, Naji, Ali, Rabinovitch, Alex, Guo, Zhiguang
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2016
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927982/
https://ncbi.nlm.nih.gov/pubmed/27413754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1620821
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki