Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human β-cell regeneration in vivo. Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) indu...

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Publicado en:J Diabetes Res
Autores principales: Ansarullah, Free, Colette, Christopherson, Jenica, Chen, Quanhai, Gao, Jie, Liu, Chengyang, Naji, Ali, Rabinovitch, Alex, Guo, Zhiguang
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927982/
https://ncbi.nlm.nih.gov/pubmed/27413754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1620821
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