Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets

Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human β-cell regeneration in vivo. Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) indu...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Diabetes Res
Auteurs principaux: Ansarullah, Free, Colette, Christopherson, Jenica, Chen, Quanhai, Gao, Jie, Liu, Chengyang, Naji, Ali, Rabinovitch, Alex, Guo, Zhiguang
Format: Artigo
Langue:Inglês
Publié: Hindawi Publishing Corporation 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927982/
https://ncbi.nlm.nih.gov/pubmed/27413754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/1620821
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires