AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics

A growing body of pathological, biomarker, genetic, and mechanistic data suggests that amyloid accumulation, as a result of changes in production, processing, and/or clearance of brain amyloid-β peptide (Aβ) concentrations, plays a key role in the pathogenesis of Alzheimer’s disease (AD). Beta-secre...

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Библиографические подробности
Опубликовано в: :J Alzheimers Dis
Главные авторы: Eketjäll, Susanna, Janson, Juliette, Kaspersson, Karin, Bogstedt, Anna, Jeppsson, Fredrik, Fälting, Johanna, Haeberlein, Samantha Budd, Kugler, Alan R., Alexander, Robert C., Cebers, Gvido
Формат: Artigo
Язык:Inglês
Опубликовано: IOS Press 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927864/
https://ncbi.nlm.nih.gov/pubmed/26890753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-150834
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