Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

A series of bicyclams have been shown to be potent and selective inhibitors of human immunodeficiency virus (HIV). The compounds are inhibitory to the replication of various HIV-1 and HIV-2 strains in various human T-cell systems, including peripheral blood lymphocytes, at 0.14-1.4 microM, without b...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	De Clercq, E, Yamamoto, N, Pauwels, R, Baba, M, Schols, D, Nakashima, H, Balzarini, J, Debyser, Z, Murrer, B A, Schwartz, D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49276/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1608936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.12.5286
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