An antiviral target on reverse transcriptase of human immunodeficiency virus type 1 revealed by tetrahydroimidazo-[4,5,1-jk] [1,4]benzodiazepin-2 (1H)-one and -thione derivatives.

Screening of pharmacologically acceptable prototype compounds has recently led to the discovery of a series of ultraselective inhibitors of human immunodeficiency virus (HIV)-1 replication, the tetrahydroimidazo[4,5,1-jk] [1,4]-benzodiazepin-2(1H)-one and -thione (TIBO) derivatives. The TIBO compoun...

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I whakaputaina i:	Proc Natl Acad Sci U S A
Ngā kaituhi matua:	Debyser, Z, Pauwels, R, Andries, K, Desmyter, J, Kukla, M, Janssen, P A, De Clercq, E
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	National Academy of Sciences 1991
Ngā marau:	Research Article
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51036/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1705038/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.4.1451
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