Neutrophil-derived IL-1β impairs efficacy of NF-κB inhibitors against lung cancer

While epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenesis in Kras(G12D) and urethane models of lung cancer. Mye...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: McLoed, Allyson G., Sherrill, Taylor P., Cheng, Dong-Sheng, Han, Wei, Saxon, Jamie A., Gleaves, Linda A., Wu, Pingsheng, Polosukhin, Vasiliy V., Karin, Michael, Yull, Fiona E., Stathopoulos, Georgios T., Georgoulias, Vassilis, Zaynagetdinov, Rinat, Blackwell, Timothy S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927403/
https://ncbi.nlm.nih.gov/pubmed/27320908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.085
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