Neutrophil-derived IL-1β impairs efficacy of NF-κB inhibitors against lung cancer

While epithelial NF-κB signaling is important for lung carcinogenesis, NF-κB inhibitors are ineffective for cancer treatment. To explain this paradox, we studied mice with genetic deletion of IKKβ in myeloid cells and found enhanced tumorigenesis in Kras(G12D) and urethane models of lung cancer. Mye...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: McLoed, Allyson G., Sherrill, Taylor P., Cheng, Dong-Sheng, Han, Wei, Saxon, Jamie A., Gleaves, Linda A., Wu, Pingsheng, Polosukhin, Vasiliy V., Karin, Michael, Yull, Fiona E., Stathopoulos, Georgios T., Georgoulias, Vassilis, Zaynagetdinov, Rinat, Blackwell, Timothy S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927403/
https://ncbi.nlm.nih.gov/pubmed/27320908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.085
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