Chronic NF-κB activation links COPD and lung cancer through generation of an immunosuppressive microenvironment in the lungs

Nuclear Factor (NF)-κB is positioned to provide the interface between COPD and carcinogenesis through regulation of chronic inflammation in the lungs. Using a tetracycline-inducible transgenic mouse model that conditionally expresses activated IκB kinase β (IKKβ) in airway epithelium (IKTA), we foun...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Zaynagetdinov, Rinat, Sherrill, Taylor P., Gleaves, Linda A., Hunt, Pierre, Han, Wei, McLoed, Allyson G., Saxon, Jamie A., Tanjore, Harikrishna, Gulleman, Peter M., Young, Lisa R., Blackwell, Timothy S.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868699/
https://ncbi.nlm.nih.gov/pubmed/26756215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6562
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