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Chemoselective Modifications for the Traceless Ligation of Thioamide-Containing Peptides and Proteins

Thioamides are single-atom substitutions of canonical amide bonds, and have been proven to be versatile and minimally perturbing probes in protein folding studies. Previously, our group showed that thioamides can be incorporated into proteins by native chemical ligation (NCL) with Cys as a ligation...

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Bibliographic Details
Published in:Org Biomol Chem
Main Authors: Wang, Yanxin J., Szantai-Kis, D. Miklos, Petersson, E. James
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927387/
https://ncbi.nlm.nih.gov/pubmed/27264841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob01020b
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