Impaired Lysosomal Function Underlies Monoclonal Light Chain–Associated Renal Fanconi Syndrome

Monoclonal gammopathies are frequently complicated by kidney lesions that increase the disease morbidity and mortality. In particular, abnormal Ig free light chains (LCs) may accumulate within epithelial cells, causing proximal tubule (PT) dysfunction and renal Fanconi syndrome (RFS). To investigate...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Luciani, Alessandro, Sirac, Christophe, Terryn, Sara, Javaugue, Vincent, Prange, Jenny Ann, Bender, Sébastien, Bonaud, Amélie, Cogné, Michel, Aucouturier, Pierre, Ronco, Pierre, Bridoux, Frank, Devuyst, Olivier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2016
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926980/
https://ncbi.nlm.nih.gov/pubmed/26614382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050581
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