Impaired Lysosomal Function Underlies Monoclonal Light Chain–Associated Renal Fanconi Syndrome

Monoclonal gammopathies are frequently complicated by kidney lesions that increase the disease morbidity and mortality. In particular, abnormal Ig free light chains (LCs) may accumulate within epithelial cells, causing proximal tubule (PT) dysfunction and renal Fanconi syndrome (RFS). To investigate...

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Bibliografische gegevens
Gepubliceerd in:J Am Soc Nephrol
Hoofdauteurs: Luciani, Alessandro, Sirac, Christophe, Terryn, Sara, Javaugue, Vincent, Prange, Jenny Ann, Bender, Sébastien, Bonaud, Amélie, Cogné, Michel, Aucouturier, Pierre, Ronco, Pierre, Bridoux, Frank, Devuyst, Olivier
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Nephrology 2016
Onderwerpen:
Basic Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926980/
https://ncbi.nlm.nih.gov/pubmed/26614382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015050581
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