Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA−/lo castration-resistant cells

We have recently demonstrated that the undifferentiated PSA(−/lo) prostate cancer (PCa) cell population harbors self-renewing long-term tumor-propagating cells that are refractory to castration, thus representing a therapeutic target. Our goals here are, by using the same lineage-tracing reporter sy...

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Bibliographic Details
Published in:	Oncotarget
Main Authors:	Rycaj, Kiera, Cho, Eun Jeong, Liu, Xin, Chao, Hsueh-Ping, Liu, Bigang, Li, Qiuhui, Devkota, Ashwini K., Zhang, Dingxiao, Chen, Xin, Moore, John, Dalby, Kevin N., Tang, Dean G.
Format:	Artigo
Language:	Inglês
Published:	Impact Journals LLC 2016
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4924710/ https://ncbi.nlm.nih.gov/pubmed/26871947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7303
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Longitudinal tracking of subpopulation dynamics and molecular changes during LNCaP cell castration and identification of inhibitors that could target the PSA−/lo castration-resistant cells

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