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Hydroxymethylation beyond Carbonylation: Enantioselective Iridium Catalyzed Reductive Coupling of Formaldehyde with Allylic Acetates via Enantiotopic π-Facial Discrimination
Chiral iridium complexes modified by SEGPHOS catalyze the 2-propanol mediated reductive coupling of branched allylic acetates 1a–1o with formaldehyde to form primary homoallylic alcohols 2a–2o with excellent control of regio- and enantioselectivity. These processes, which rely on enantiotopic π-faci...
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| Veröffentlicht in: | J Am Chem Soc |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4924615/ https://ncbi.nlm.nih.gov/pubmed/26958737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b01078 |
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