Development and validation of a UPLC–MS/MS method for the simultaneous determination of paritaprevir and ritonavir in rat liver

AIM: Determination of paritaprevir and ritonavir in rat liver tissue samples. RESULTS: We successfully validated a UPLC–MS/MS method to measure paritaprevir and ritonavir in rat liver using deuterated internal standards (d8-paritapervir and d6-ritonavir). The method is linear from 20 to 20,000 and 5...

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Bibliographische Detailangaben
Veröffentlicht in:Bioanalysis
Hauptverfasser: Ocque, Andrew J, Hagler, Colleen E, Difrancesco, Robin, Woolwine-Cunningham, Yvonne, Bednasz, Cindy J, Morse, Gene D, Talal, Andrew H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Science Ltd 2016
Schlagworte:
Methodology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924549/
https://ncbi.nlm.nih.gov/pubmed/27277877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4155/bio-2016-0040
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