Hepatic Pharmacokinetics and Pharmacodynamics With Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir Treatment and Variable Ribavirin Dosage

BACKGROUND: It is unknown whether ribavirin (RBV) coadministration modifies the early rate of decline of hepatitis C virus (HCV) RNA in the liver versus plasma compartments, specifically. METHODS: This partially randomized, open-label, phase 2 study enrolled treatment-naive, noncirrhotic patients wi...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Talal, Andrew H, Dumas, Emily O, Bauer, Barbara, Rejman, Richard M, Ocque, Andrew, Morse, Gene D, Lucic, Danijela, Cloherty, Gavin A, King, Jennifer, Zha, Jiuhong, Zhang, Hongtao, Cohen, Daniel E, Shulman, Nancy, Pawlotsky, Jean-Michel, Hézode, Christophe
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853515/
https://ncbi.nlm.nih.gov/pubmed/29228392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix495
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