Hepatic Pharmacokinetics and Pharmacodynamics With Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir Treatment and Variable Ribavirin Dosage

BACKGROUND: It is unknown whether ribavirin (RBV) coadministration modifies the early rate of decline of hepatitis C virus (HCV) RNA in the liver versus plasma compartments, specifically. METHODS: This partially randomized, open-label, phase 2 study enrolled treatment-naive, noncirrhotic patients wi...

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Vydáno v:J Infect Dis
Hlavní autoři: Talal, Andrew H, Dumas, Emily O, Bauer, Barbara, Rejman, Richard M, Ocque, Andrew, Morse, Gene D, Lucic, Danijela, Cloherty, Gavin A, King, Jennifer, Zha, Jiuhong, Zhang, Hongtao, Cohen, Daniel E, Shulman, Nancy, Pawlotsky, Jean-Michel, Hézode, Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853515/
https://ncbi.nlm.nih.gov/pubmed/29228392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix495
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