Hepatic Pharmacokinetics and Pharmacodynamics With Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir Treatment and Variable Ribavirin Dosage

BACKGROUND: It is unknown whether ribavirin (RBV) coadministration modifies the early rate of decline of hepatitis C virus (HCV) RNA in the liver versus plasma compartments, specifically. METHODS: This partially randomized, open-label, phase 2 study enrolled treatment-naive, noncirrhotic patients wi...

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Bibliografiske detaljer
Udgivet i:J Infect Dis
Main Authors: Talal, Andrew H, Dumas, Emily O, Bauer, Barbara, Rejman, Richard M, Ocque, Andrew, Morse, Gene D, Lucic, Danijela, Cloherty, Gavin A, King, Jennifer, Zha, Jiuhong, Zhang, Hongtao, Cohen, Daniel E, Shulman, Nancy, Pawlotsky, Jean-Michel, Hézode, Christophe
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853515/
https://ncbi.nlm.nih.gov/pubmed/29228392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix495
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