In vivo gene editing in dystrophic mouse muscle and muscle stem cells

Frame-disrupting mutations in the DMD gene, encoding dystrophin, compromise myofiber integrity and drive muscle deterioration in Duchenne muscular dystrophy (DMD). Removing one or more exons from the mutated transcript can produce an in-frame mRNA and a truncated but still functional protein. In thi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Tabebordbar, Mohammadsharif, Zhu, Kexian, Cheng, Jason K.W., Chew, Wei Leong, Widrick, Jeffrey J., Yan, Winston X., Maesner, Claire, Wu, Elizabeth Y., Xiao, Ru, Ran, F. Ann, Cong, Le, Zhang, Feng, Vandenberghe, Luk H., Church, George M., Wagers, Amy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924477/
https://ncbi.nlm.nih.gov/pubmed/26721686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5177
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados