Translational Features of Human Alpha 2b Interferon Production in Escherichia coli

The yield of human alpha 2b interferon in Escherichia coli was optimized by replacement of low-usage arginine codons located in the mRNA 5′ end. The differences observed among the various gene variants suggest that codon usage, Shine-Dalgarno-like sequences, and mRNA secondary structure contribute t...

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Bibliographic Details
Main Authors: Valente, C. A., Prazeres, D. M. F., Cabral, J. M. S., Monteiro, G. A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Physiology and Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC492429/
https://ncbi.nlm.nih.gov/pubmed/15294846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.8.5033-5036.2004
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