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WISP1-αvβ3 integrin signaling positively regulates TLR-triggered inflammation response in sepsis induced lung injury

We recently noted that the matricellular protein WISP1 contributes to sepsis induced acute lung injury (ALI) via integrin β6. In the current study, we pursued further aspects of WISP1 modulation of TLR signaling in lungs of mice after sepsis and TLR4 mediated release of TNF-α in macrophages. After c...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Chen, Zhixia, Ding, Xibing, Jin, Shuqing, Pitt, Bruce, Zhang, Liming, Billiar, Timothy, Li, Quan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923866/
https://ncbi.nlm.nih.gov/pubmed/27349568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28841
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