Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes

Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus. While currently available preclinical safety models have been used for evaluating vector safety, none ha...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Zhou, Sheng, Fatima, Soghra, Ma, Zhijun, Wang, Yong-Dong, Lu, Taihe, Janke, Laura J, Du, Yang, Sorrentino, Brian P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923324/
https://ncbi.nlm.nih.gov/pubmed/26957223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.55
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