Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients

Recombinant adeno-associated viral vectors (rAAV) currently constitute a real therapeutic strategy for the sustained correction of diverse genetic conditions. Though a wealth of preclinical and clinical studies have been conducted with rAAV, the oncogenic potential of these vectors is still controve...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther
Auteurs principaux: Gil-Farina, Irene, Fronza, Raffaele, Kaeppel, Christine, Lopez-Franco, Esperanza, Ferreira, Valerie, D'Avola, Delia, Benito, Alberto, Prieto, Jesus, Petry, Harald, Gonzalez-Aseguinolaza, Gloria, Schmidt, Manfred
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923321/
https://ncbi.nlm.nih.gov/pubmed/26948440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.52
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